Xenobiotics: Drug Quantitation and Modeling
Xenobiotics are chemical compounds that originate outside the human body - such as medications, environmental contaminants, dietary chemicals, or pollutants - that can be transferred from the mother into human milk and subsequently ingested by the infant.
MAC offers quantitative modeling and simulation to characterize the transfer, concentration-time profiles, and variability of drugs and bioactive compounds between maternal plasma, human milk, and the infant. By integrating clinical data with population pharmacokinetic and exposure models, this approach supports evidence-based lactation safety assessments, dose optimization for lactating individuals, and improved understanding of infant exposure and risk-benefit relationships.
Leveraging MAC's MPRINT Companion Core
MAC is one of two research cores established as part of the UC San Diego Center for Excellence in Therapeutics in the NIH/NICHD-funded MPRINT Hub. Our companion core is the Pharmacometrics and Analytical Chemistry Core (PACC), which specializes in high-precision quantitative analysis of drugs, metabolites, and biomarkers across challenging sample matrices.
From Raw Data to Actionable Interpretation
Using state-of-the-art quantitative mass spectrometry platforms, PACC delivers robust targeted assays optimized for small sample volumes, including plasma, tissue homogenates, and complex biological fluids - with a particular emphasis on human milk. Analytical workflows emphasize sensitivity, specificity, and reproducibility to support pharmacokinetic and pharmacodynamic investigations.
In parallel with quantitative analytics, PACC offers advanced pharmacometrics expertise, transforming concentration-time and biomarker data into mechanistic models. These models help characterize drug ADME properties, inform dose selection, and support translational extrapolation across populations. By integrating bioanalytical rigor with modeling science, PACC provides comprehensive analytical support from raw data to actionable interpretation.
Interested in Xenobiotics?
Investigators interested in novel assay development, quantitative measurements, or model-based analyses are encouraged to connect to explore how we can support your research goals.
Interested in Other Human Milk Components?
Visit our platform overview or select individual classes below.
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